Restoration of vancomycin susceptibility in Enterococcus faecalis by antiresistance determinant gene transfer.
نویسندگان
چکیده
We assessed the ability of gene transfer to reverse vancomycin resistance in class A (VanA) glycopeptide-resistant Enterococcus faecalis. Recombinant shuttle vectors containing a vanH promoter-vanA antisense gene cassette fully restored vancomycin susceptibility through a combined transcriptional activator binding domain decoy and inducible vanA antisense RNA effect.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 45 3 شماره
صفحات -
تاریخ انتشار 2001